ME:AO is set in the universe of Bioware's Mass Effect games.
All three games are considered canon, and specific decision points are laid out on the wiki: http://me-alphaomega.com/wiki/Canon
The Reaper Wars ended when Commander Shepard gave her life to destroy all non-organic life in the galaxy, including the Reapers, the Geth, and all AIs. Now, people of all species and homeworlds are left to pick up the pieces. Many have made their way to the lawless edge of the Galaxy: Omega.
Here, criminals, terrorists, and malcontents make their home. Added to that are thousands of refugees fleeing the remains of their Reaper-destroyed homeworlds.
Here, the members of the newly-formed Alpha Phoenix mercenary band are scrambling to make a name for themselves in what's left of the universe.
We are a code-light, RP-heavy game. We have no coded space system, combat system, etc. Instead, we have lots of excellent story.
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